ENCLOMIPHENE
Enclomiphene is in a class of medications called Selective Estrogen Receptor Modulators ( SERMs ). These medications (taken in pill-form) have historically been used to treat infertility in women but have become popular as an off-label treatment for hypogonadal men (men suffering from both low testosterone and low sperm count).
How does Enclomiphene (SERMs) work?
The pituitary gland (in the brain) is responsible for sending chemical messengers (Follicle Stimulating Hormone and Luteinizing Hormone) to the testicles resulting in sperm production and testosterone production. If elevation in the level of testosterone will be sensed by the pituitary gland resulting in a decrease of FSH and LH production (negative feedback cycle).
SERMs work by blocking the pituitary’s response to testosterone in blood stream, resulting in an increased production of FSH and LH, and therefore more stimulus to the testicles to produce testosterone and sperm.
Advantages of Enclomiphene (SERMs)
If patients are hypogonadal and still wish to have children, then Enclomiphene may be an optimal method of treating both low testosterone levels and low sperm count. If patients tend to have elevated red blood cell counts (polycythemia) while on testosterone therapy, they may notice less polycythemia on SERMs.
If patients do not like the thought of injecting themselves with testosterone or undergoing pellet implantation, Enclomiphene may be a great options because it is administered as a once-a day oral tablet.
Most Common Side Effects of Enclomiphene (SERMs)
The most common side effects reported by patients (when treated more than 3 years) included mood changes, visual blurring, and breast tenderness (1)
Is Enclomiphene covered by insurance?
Because we are using a SERM for off-label use, this is not a covered service.
How do I get started with Enclomiphene?
If you are experiencing testosterone deficiency symptoms and are interested in Enclomiphene, getting started is similar to that of pellet therapy and microdosing. Go to Getting Started for more details.
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